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Fine-tuning large AI models with small add-ons to predict brain activity

Zhuofan Josh Ying, Guanglong Sun, Nolan Ho, Kieran Liu, Rui Yang, Andrew Chen · Submitted Oct 19, 2026 · 231 upvotes yesterday
Preprint · not peer reviewedTrending

Brain encoding models try to predict how the brain responds to sights and sounds. Brain data is scarce, so big models are usually frozen and only a small readout is trained. The authors instead attach small trainable add-ons called LoRA adapters to models with up to 104 billion parameters. They also predict several time points in one pass to save compute.

Key finding: Their method, BrainLoRA, improved results across nine models and set the best published score on the Algonauts 2025 Challenge. An ensemble of more than 200 adapted models ranked first on the public leaderboard.

Why it matters: It shows that large AI models can be adapted cheaply even when training data is scarce and costly.